Poor recycling of BACE1 enzyme could promote Alzheimer's disease
Sluggish recycling of a protein-slicing enzyme could promote Alzheimer's disease, according to a study published online on November 21 in The Journal of Cell Biology.
View ArticleStudy reveals insight into how key protein protects against viral infections
Scientists from the University of Utah School of Medicine have discovered that a mouse protein called IFITM3 contributes to the body's defense against some types of viral infections by binding to an...
View ArticleTargeted gene silencing drugs are more than 500 times more effective with new...
Small interfering RNAs (siRNAs) are a potent new drug class that can silence a disease-causing gene, but delivering them to a target cell can be challenging. An innovative delivery approach that...
View ArticleMisregulated genes may have big autism role
A new study finds that two genes individually associated with rare autism-related disorders are also jointly linked to more general forms of autism. The finding suggests a new genetic pathway to...
View ArticleExit discovered in cellular garbage truck: Immersed in the inner workings of...
At the University of Geneva (UNIGE), the team led by Professor Jean Gruenberg has long been interested in the movement of lysosomes, the sub-compartments of cells to where endocytic vesicles deliver...
View ArticleAutism gene stunts neurons, but growth can be restored, in mice
Brown University researchers have traced a genetic deficiency implicated in autism in humans to specific molecular and cellular consequences that cause clear deficits in mice in how well neurons can...
View ArticleDiametric shift in 2 protein levels spurs Alzheimer's plaque accumulation
A diametric shift in the levels of two proteins involved in folding, moving and cutting other proteins enables accumulation of the destructive brain plaque found in Alzheimer's disease, researchers...
View ArticleStudy: Prazosin inhibits endocytic sorting
In a study just published in Proceedings of the National Academy of Sciences, Dr Ulrike Eggert et al. demonstrated that the drug Prazosin inhibits endocytic sorting.
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